AustralieFrV1, Main, Exploration, bibRecord, 006A12

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Identifieur interne : 006A12 ( Main/Exploration ); précédent : 006A11; suivant : 006A13

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Auteurs : Paul B. Chapman [États-Unis] ; Axel Hauschild [Allemagne] ; Caroline Robert [France] ; John B. Haanen [Pays-Bas] ; Paolo Ascierto [Italie] ; James Larkin [États-Unis] ; Reinhard Dummer [Suisse] ; Claus Garbe [Allemagne] ; Alessandro Testori [Italie] ; Michele Maio [Italie] ; David Hogg [Canada] ; Paul Lorigan [Royaume-Uni] ; Celeste Lebbe [France] ; Thomas Jouary [France] ; Dirk Schadendorf [Allemagne] ; Antoni Ribas [États-Unis] ; Steven J. O'Day [États-Unis] ; Jeffrey A. Sosman [États-Unis] ; John M. Kirkwood [États-Unis] ; Alexander M. M. Eggermont [France] ; Brigitte Dreno [France] ; Keith Nolop [États-Unis] ; JIANG LI [Royaume-Uni, États-Unis] ; Betty Nelson [États-Unis] ; Jeannie Hou [États-Unis] ; Richard J. Lee [États-Unis] ; Keith T. Flaherty [États-Unis] ; Grant A. Mcarthur [Australie]

Source :

The New England journal of medicine [ 0028-4793 ] ; 2011.

RBID : Pascal:11-0309403

Descripteurs français

Pascal (Inist)
- Mélanome malin, Survie, Protooncogène, Gène onc cellulaire, Mutation, Génétique, Médecine, Gène BRAF.
Wicri :
- topic : Génétique, Médecine.

English descriptors

KwdEn :
- BRAF Gene, C-Onc gene, Genetics, Malignant melanoma, Medicine, Mutation, Protooncogene, Survival.

Abstract

BACKGROUND Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032) have shown response rates of more than 50% in patients with metastatic melanoma with the BRAF V600E mutation. METHODS We conducted a phase 3 randomized clinical trial comparing vemurafenib with dacarbazine in 675 patients with previously untreated, metastatic melanoma with the BRAF V600E mutation. Patients were randomly assigned to receive either vemurafenib (960 mg orally twice daily) or dacarbazine (1000 mg per square meter of body-surface area intravenously every 3 weeks). Coprimary end points were rates of overall and progression-free survival. Secondary end points included the response rate, response duration, and safety. A final analysis was planned after 196 deaths and an interim analysis after 98 deaths. RESULTS At 6 months, overall survival was 84% (95% confidence interval [CI], 78 to 89) in the vemurafenib group and 64% (95% CI, 56 to 73) in the dacarbazine group. In the interim analysis for overall survival and final analysis for progression-free survival, vemurafenib was associated with a relative reduction of 63% in the risk of death and of 74% in the risk of either death or disease progression, as compared with dacarbazine (P<0.001 for both comparisons). After review of the interim analysis by an independent data and safety monitoring board, crossover from dacarbazine to vemurafenib was recommended. Response rates were 48% for vemurafenib and 5% for dacarbazine. Common adverse events associated with vemurafenib were arthralgia, rash, fatigue, alopecia, keratoacanthoma or squamous-cell carcinoma, photosensitivity, nausea, and diarrhea; 38% of patients required dose modification because of toxic effects. CONCLUSIONS Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation. (Funded by Hoffmann-La Roche; BRIM-3 ClinicalTrials.gov number, NCT01006980.).

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
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<author><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A." last="Mcarthur">Grant A. Mcarthur</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation</title>
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<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine, Memorial Sloan-Kettering Cancer Center</s1>
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<author><name sortKey="Hauschild, Axel" sort="Hauschild, Axel" uniqKey="Hauschild A" first="Axel" last="Hauschild">Axel Hauschild</name>
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<s2>Kiel</s2>
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<author><name sortKey="Robert, Caroline" sort="Robert, Caroline" uniqKey="Robert C" first="Caroline" last="Robert">Caroline Robert</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institut Gustave Roussy, Hôpital Saint Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haanen, John B" sort="Haanen, John B" uniqKey="Haanen J" first="John B." last="Haanen">John B. Haanen</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Netherlands Cancer Institute</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
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<placeName><settlement type="city">Amsterdam</settlement>
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<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Istituto Nazionale Tumori Fondazione Pascale</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto Nazionale Tumori Fondazione Pascale</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Larkin, James" sort="Larkin, James" uniqKey="Larkin J" first="James" last="Larkin">James Larkin</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine, Memorial Sloan-Kettering Cancer Center</s1>
<s2>New York</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name>
<affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Department of Dermatology, University of Zurich</s1>
<s2>Zurich</s2>
<s3>CHE</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<placeName><settlement type="city">Zurich</settlement>
<region nuts="3" type="region">Canton de Zurich</region>
</placeName>
<orgName type="university">Université de Zurich</orgName>
</affiliation>
</author>
<author><name sortKey="Garbe, Claus" sort="Garbe, Claus" uniqKey="Garbe C" first="Claus" last="Garbe">Claus Garbe</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>University ofTubingen</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Testori, Alessandro" sort="Testori, Alessandro" uniqKey="Testori A" first="Alessandro" last="Testori">Alessandro Testori</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Istituto Europeo di Oncologia</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Istituto Toscano Tumori</s1>
<s2>Florence</s2>
<s3>ITA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Istituto Toscano Tumori</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Princess Margaret Hospital and University Health Network</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Princess Margaret Hospital and University Health Network</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lorigan, Paul" sort="Lorigan, Paul" uniqKey="Lorigan P" first="Paul" last="Lorigan">Paul Lorigan</name>
<affiliation wicri:level="4"><inist:fA14 i1="14"><s1>University of Manchester</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
</author>
<author><name sortKey="Lebbe, Celeste" sort="Lebbe, Celeste" uniqKey="Lebbe C" first="Celeste" last="Lebbe">Celeste Lebbe</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Service de Dermatologie, Hôpital Saint Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jouary, Thomas" sort="Jouary, Thomas" uniqKey="Jouary T" first="Thomas" last="Jouary">Thomas Jouary</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Saint Andre Hospital</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schadendorf, Dirk" sort="Schadendorf, Dirk" uniqKey="Schadendorf D" first="Dirk" last="Schadendorf">Dirk Schadendorf</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University Hospital Essen</s1>
<s2>Essen</s2>
<s3>DEU</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Essen</wicri:noRegion>
<wicri:noRegion>University Hospital Essen</wicri:noRegion>
<wicri:noRegion>University Hospital Essen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ribas, Antoni" sort="Ribas, Antoni" uniqKey="Ribas A" first="Antoni" last="Ribas">Antoni Ribas</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Medicine, David Geffen School of Medicine at UCLA</s1>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Department of Medicine, David Geffen School of Medicine at UCLA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="O Day, Steven J" sort="O Day, Steven J" uniqKey="O Day S" first="Steven J." last="O'Day">Steven J. O'Day</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Angeles Clinic and Research Institute</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sosman, Jeffrey A" sort="Sosman, Jeffrey A" uniqKey="Sosman J" first="Jeffrey A." last="Sosman">Jeffrey A. Sosman</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Medicine, Vanderbilt University School of Medicine</s1>
<s2>Nashville</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kirkwood, John M" sort="Kirkwood, John M" uniqKey="Kirkwood J" first="John M." last="Kirkwood">John M. Kirkwood</name>
<affiliation wicri:level="3"><inist:fA14 i1="20"><s1>Department of Medicine, University of Pittsburgh School of Medicine</s1>
<s2>Pittsburgh</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eggermont, Alexander M M" sort="Eggermont, Alexander M M" uniqKey="Eggermont A" first="Alexander M. M." last="Eggermont">Alexander M. M. Eggermont</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Institut Gustave Roussy, Hôpital Saint Louis</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dreno">Brigitte Dreno</name>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Dermatology, Nantes University Hospital</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nolop, Keith" sort="Nolop, Keith" uniqKey="Nolop K" first="Keith" last="Nolop">Keith Nolop</name>
<affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Plexxikon</s1>
<s2>Berkeley, CA</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Plexxikon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jiang Li" sort="Jiang Li" uniqKey="Jiang Li" last="Jiang Li">JIANG LI</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Medical Oncology, Royal Marsden Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Hoffmann-La Roche</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Hoffmann-La Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nelson, Betty" sort="Nelson, Betty" uniqKey="Nelson B" first="Betty" last="Nelson">Betty Nelson</name>
<affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Genentech</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hou, Jeannie" sort="Hou, Jeannie" uniqKey="Hou J" first="Jeannie" last="Hou">Jeannie Hou</name>
<affiliation wicri:level="3"><inist:fA14 i1="23"><s1>Genentech</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lee, Richard J" sort="Lee, Richard J" uniqKey="Lee R" first="Richard J." last="Lee">Richard J. Lee</name>
<affiliation wicri:level="1"><inist:fA14 i1="22"><s1>Hoffmann-La Roche</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Hoffmann-La Roche</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Flaherty, Keith T" sort="Flaherty, Keith T" uniqKey="Flaherty K" first="Keith T." last="Flaherty">Keith T. Flaherty</name>
<affiliation wicri:level="3"><inist:fA14 i1="24"><s1>Department of Medicine, Massachusetts General Hospital</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A." last="Mcarthur">Grant A. Mcarthur</name>
<affiliation wicri:level="1"><inist:fA14 i1="25"><s1>Peter MacCallum Cancer Center</s1>
<s2>Melbourne, VIC</s2>
<s3>AUS</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Peter MacCallum Cancer Center</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BRAF Gene</term>
<term>C-Onc gene</term>
<term>Genetics</term>
<term>Malignant melanoma</term>
<term>Medicine</term>
<term>Mutation</term>
<term>Protooncogene</term>
<term>Survival</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Mélanome malin</term>
<term>Survie</term>
<term>Protooncogène</term>
<term>Gène onc cellulaire</term>
<term>Mutation</term>
<term>Génétique</term>
<term>Médecine</term>
<term>Gène BRAF</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">BACKGROUND Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032) have shown response rates of more than 50% in patients with metastatic melanoma with the BRAF V600E mutation. METHODS We conducted a phase 3 randomized clinical trial comparing vemurafenib with dacarbazine in 675 patients with previously untreated, metastatic melanoma with the BRAF V600E mutation. Patients were randomly assigned to receive either vemurafenib (960 mg orally twice daily) or dacarbazine (1000 mg per square meter of body-surface area intravenously every 3 weeks). Coprimary end points were rates of overall and progression-free survival. Secondary end points included the response rate, response duration, and safety. A final analysis was planned after 196 deaths and an interim analysis after 98 deaths. RESULTS At 6 months, overall survival was 84% (95% confidence interval [CI], 78 to 89) in the vemurafenib group and 64% (95% CI, 56 to 73) in the dacarbazine group. In the interim analysis for overall survival and final analysis for progression-free survival, vemurafenib was associated with a relative reduction of 63% in the risk of death and of 74% in the risk of either death or disease progression, as compared with dacarbazine (P<0.001 for both comparisons). After review of the interim analysis by an independent data and safety monitoring board, crossover from dacarbazine to vemurafenib was recommended. Response rates were 48% for vemurafenib and 5% for dacarbazine. Common adverse events associated with vemurafenib were arthralgia, rash, fatigue, alopecia, keratoacanthoma or squamous-cell carcinoma, photosensitivity, nausea, and diarrhea; 38% of patients required dose modification because of toxic effects. CONCLUSIONS Vemurafenib produced improved rates of overall and progression-free survival in patients with previously untreated melanoma with the BRAF V600E mutation. (Funded by Hoffmann-La Roche; BRIM-3 ClinicalTrials.gov number, NCT01006980.).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
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<li>Lombardie</li>
<li>Massachusetts</li>
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</country>
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</region>
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<country name="Canada"><noRegion><name sortKey="Hogg, David" sort="Hogg, David" uniqKey="Hogg D" first="David" last="Hogg">David Hogg</name>
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</region>
<name sortKey="Jiang Li" sort="Jiang Li" uniqKey="Jiang Li" last="Jiang Li">JIANG LI</name>
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<country name="Australie"><noRegion><name sortKey="Mcarthur, Grant A" sort="Mcarthur, Grant A" uniqKey="Mcarthur G" first="Grant A." last="Mcarthur">Grant A. Mcarthur</name>
</noRegion>
</country>
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</affiliations>
</record>

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{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
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   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:11-0309403
   |texte=   Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
}}

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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

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Descripteurs français

English descriptors

Abstract

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